Atmospheric cold plasma

cold plasma icon
Plasma is created by exciting a gas through the introduction of energy, for example using high voltage.

Various technical principles can be used to generate atmospheric cold plasma. The ActivCellpen uses dielectric materials, i.e. materials that are weakly or not at all conductive, which allow discharge pulses to be transferred to a conductive surface such as human skin.

The resulting cold plasma comprises numerous physical and chemical components. The combination of these components is ultimately responsible for the medicinal effect.

Due to the weak electrical currents, the technology is completely safe for patients.

Method of action of cold plasma

Stimulates cell activity

Cold plasma stimulates cell metabolism. It accelerates cell division and cell growth and thus demonstrably promotes the healing process. The stimulation of various cellular signalling pathways and growth factors has a favourable influence on tissue remodelling.

Cold plasma also reduces inflammation and has a positive effect on the immune system.

Promotes blood flow

Cold plasma has an immediate and lasting hyperaemic effect on tissue.
It stimulates the formation of new blood vessels, increases micro-circulation in the tissue and thus improves its metabolism. The tissue is therefore better supplied with oxygen and the pH value falls. All of these effects accelerate wound healing.

Antiseptic effect

The reactive species of cold atmospheric plasma have an anti-microbial effect. Due to their non-specific mechanism of action, a development of resistance is impossible. Cold plasma can therefore also be used successfully against multi-resistant micro-organisms such as Staphylococcus aureus (MRSA in humans) and Staphylococcus pseudointermedius (MRSP in animals). Cold plasma is also effective against viruses and can impair certain parasites.

The use of cold plasma technology in medicine

The temperature of cold plasma is less than 40°C and it is well tolerated by tissue. This type of therapy therefore is ideal for the treatment of body surfaces. Various properties of the reactive species contained in cold plasma come to play in this therapy. The use of cold plasma in human medicine is an established practice, and numerous studies have demonstrated its efficacy. Its biofilm-inhibiting effect and improvement of the wound environment are used to particularly good effect on chronic wounds, increasing the efficiency of treatment. The rapid effect and high tolerability of this treatment contribute to its widespread acceptance.

Cold plasma therapy equipment for veterinary medicine

With the Cellpen® device series, ActivCell Group AG has succeeded in integrating cold plasma technology into a small, cordless device that allows modern plasma medicine to be used in daily practice. In order to cover the different needs of human and veterinary medicine, various device types are available and are constantly undergoing further development. The easily manageable cold plasma therapy devices have been tested according to DIN SPEC 91315, General Requirements for Medical Plasma Sources, by the Leibniz Institute for Plasma Research and Technology (Leibniz-Institut für Plasmaforschung und Technologie e.V.).

Cold plasma therapy device for horses


Cold plasma therapy equipment for small animals